Related Experiment Video
Updated: Jun 25, 2025
13:12
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
Published on: August 12, 2019
45.4K
RAPNO efforts in Brain Tumour Outcomes
Qurat-Ul-Ain Virani1, Zanib Javed1, Muhammad Shahzad Shamim1
1Section of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan.
Summary
Treatment response assessment for brain tumors has advanced from MacDonald
Area of Science:
- Neuro-oncology
- Medical imaging
- Clinical trial methodology
Background:
- Evaluating brain tumor treatment effectiveness has historically relied on imaging.
- MacDonald criteria were early standards but had limitations in distinguishing true progression from pseudo-progression and assessing non-enhancing disease.
- The Response Assessment in Neuro-Oncology (RANO) working group was formed to address these limitations.
Purpose of the Study:
- To review the evolution of brain tumor response assessment criteria.
- To highlight the development and application of RANO and RAPNO criteria.
- To summarize the six published response criteria for neuro-oncology.
Main Methods:
- Literature review of established neuro-oncology response criteria.
- Analysis of the development and rationale behind RANO and RAPNO criteria.
- Synthesis of information on six distinct response assessment guidelines.
Main Results:
- MacDonald criteria, while pioneering, had limitations.
- RANO criteria improved response assessment for adult brain tumors.
- RAPNO criteria were specifically developed for pediatric brain tumors due to their unique characteristics.
Conclusions:
- Response assessment criteria for brain tumors have significantly evolved.
- RANO and RAPNO criteria offer more accurate evaluation of treatment efficacy.
- Six distinct criteria now guide neuro-oncology treatment response evaluation.
