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A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

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Published on: March 17, 2023

NIR-II Fluorescence Imaging for In Vivo Quantitative Analysis.

Hua-Jie Chen¹, Lei Wang², Han Zhu²

¹Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, P. R. China.

ACS Applied Materials & Interfaces

|May 24, 2024

Summary

Near-infrared-II (NIR-II) bioimaging offers high-resolution, deep-tissue visualization for disease analysis. This review highlights advances and applications of NIR-II fluorescence imaging for in vivo qualitative and quantitative analysis.

Keywords:

NIR-II bioimaging fluorescence in vivo imaging lifetime quantitative analysis

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Area of Science:

Biomedical Engineering
Medical Imaging
Optical Spectroscopy

Background:

In vivo real-time analysis is crucial for diagnosing and treating diseases like tumors.
Near-infrared-II (NIR-II) bioimaging utilizes fluorescent materials for enhanced visualization.
NIR-II offers reduced photon scattering and low autofluorescence for improved imaging depth and resolution.

Purpose of the Study:

To review recent advancements in NIR-II bioimaging.
To detail strategies for quantitative analysis using NIR-II fluorescence.
To illustrate the applications of NIR-II imaging in vivo.

Main Methods:

Summarizing recent progress in NIR-II imaging techniques.
Describing fluorescent probe selection and quantitative analysis strategies.
Presenting representative applications of NIR-II fluorescence imaging.

Main Results:

NIR-II bioimaging provides high resolution and deep tissue penetration.
Fluorescent materials in the NIR-II region enable superior in vivo imaging.
NIR-II fluorescence imaging is a powerful tool for in vivo quantitative analysis.

Conclusions:

NIR-II fluorescence imaging has significant potential for in vivo qualitative and quantitative analysis.
Recent advances have established NIR-II imaging as an important diagnostic tool.
Future research should address remaining challenges and explore new possibilities in NIR-II imaging.