Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of macrophage autophagy and mitochondrial metabolic reprogramming in the treatment of myocardial infarction.

Journal of translational medicine·2026
Same author

Progress in precision drug delivery systems for neurodegenerative diseases with muscle atrophy.

Neuropharmacology·2026
Same author

Association of sensory impairment severity and assistive device use with prevalent and incident motoric cognitive risk syndrome.

BMC geriatrics·2025
Same author

Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels.

Signal transduction and targeted therapy·2025
Same author

Elucidating cooking-driven flavor dynamics of paddy field carp (Cyprinus carpio) using a combination of E-nose, E-tongue, GC-MS and GC-IMS.

Food chemistry·2025
Same author

The Association Between Neutrophil-to-Lymphocyte Ratio, Atherogenic Index of Plasma, and Cardiovascular Disease Incidence.

Mediators of inflammation·2025
Same journal

Development and Validation of a Pathomics Model for Prognosis Prediction in Neoadjuvant Therapy-Treated Breast Cancer: A Retrospective, Multicenter Study.

MedComm·2026
Same journal

Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy.

MedComm·2026
Same journal

Osimertinib Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Mechanisms and Therapeutic Strategies.

MedComm·2026
Same journal

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management.

MedComm·2026
Same journal

Metabolic Dysfunction-Associated Fatty Liver Disease: From Pathogenesis to Treatment.

MedComm·2026
Same journal

Dexmedetomidine Rapidly Relieves Stress-Induced Hyperalgesia via Presynaptic <i>α</i>2-Adrenergic Inhibition at Orbitofrontal-Insular Glutamatergic Synapses.

MedComm·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2025

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
09:06

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma

Published on: November 11, 2021

2.5K

CD44 and its implication in neoplastic diseases.

Yiming Xu1, Ziyi Bai1, Tianxia Lan1

  • 1Department of Biotherapy Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University Chengdu Sichuan China.

Medcomm
|May 24, 2024
PubMed
Summary
This summary is machine-generated.

CD44, a cell surface receptor, has standard (CD44s) and variant (CD44v) isoforms that play complex roles in cancer progression. Understanding these CD44 isoforms is crucial for developing targeted cancer therapies.

Keywords:
CD44neoplastic diseasessignaling pathwaystherapeutic strategies

More Related Videos

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

8.5K
Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

10.2K

Related Experiment Videos

Last Updated: Jun 25, 2025

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
09:06

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma

Published on: November 11, 2021

2.5K
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

8.5K
Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

10.2K

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • CD44 is a transmembrane glycoprotein acting as a cell surface receptor.
  • It serves as a marker for cancer stem cells and immune cells.
  • Alternative splicing of the CD44 gene yields standard (CD44s) and variant (CD44v) isoforms.

Purpose of the Study:

  • To review the functional and structural roles of CD44 isoforms in cancer pathogenesis.
  • To summarize CD44's regulatory functions in cancer-associated signaling pathways.
  • To provide an overview of CD44-targeted anticancer therapies and clinical trials.

Main Methods:

  • Literature review and synthesis of existing research on CD44.
  • Analysis of CD44's role in cancer proliferation, invasion, metastasis, and drug resistance.
  • Examination of preclinical and clinical data for CD44-targeted therapies.

Main Results:

  • CD44 isoforms (CD44s and CD44v) have overlapping or contradictory roles in tumor initiation and progression.
  • Aberrant CD44 expression contributes to tumor development.
  • CD44 isoforms regulate various signaling pathways involved in cancer.

Conclusions:

  • CD44 plays a significant role in the pathogenic mechanisms of multiple cancers.
  • Targeting CD44 presents a promising strategy for novel cancer treatments.
  • Further research into CD44 isoform-specific functions may refine therapeutic approaches.