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Merkel Cell Polyomavirus And Their Association With The Pathogenesis Of Cervical Squamous Cell Carcinomas And Adenocarcinomas: A Review Article.

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Merkel Cell Polyomavirus And Their Association With The Pathogenesis Of Cervical Squamous Cell Carcinomas And Adenocarcinomas: A Review Article.

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Merkel Cell Polyomavirus Infection and Detection

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Merkel Cell Polyomavirus and their Association with the Pathogenesis of Cervical Squamous Cell Carcinomas and

Hatim Makhdoom¹

¹Applied Medical Sciences College, Laboratory Technology Department, Taibah University, Al-Madinah Al-Munwarah, Jeddah, north Obhur, Abdullah Althagfi.

Ethiopian Journal of Health Sciences

|May 24, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Merkel Cell Polyomavirus (MCPyV) is not currently linked to cervical cancers. Further research is needed to confirm the lack of association between MCPyV and cervical squamous cell carcinomas and adenocarcinomas.

Keywords:

Adenocarcinomas Cervical Cancer Merkel Cell Polyomavirus Pathogenesis Squamous Cell Carcinomas

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Area of Science:

Oncology
Virology
Pathogenesis

Background:

Cervical cancer remains a significant global health concern.
Merkel Cell Polyomavirus (MCPyV) is a known human polyomavirus.
The potential role of MCPyV in cervical carcinogenesis is under investigation.

Purpose of the Study:

To systematically review and determine the association between Merkel Cell Polyomavirus (MCPyV) and the pathogenesis of cervical squamous cell carcinomas and adenocarcinomas.

Main Methods:

A PRISMA systematic literature search was performed across six major databases (Scopus, Web of Science, PubMed, EMBASE, Google Scholar, MEDLINE) up to September 2022.
Included studies focused on the contribution of MCPyV to cervical squamous cell carcinomas and adenocarcinomas.
Six cross-sectional studies, published between 2012-2016, involving 1135 participants (aged 18-75) were analyzed.

Main Results:

Out of 6806 initially identified articles, only six met the inclusion criteria.
Five of the included studies found no statistically significant association between MCPyV and cervical cancers.
One study reported a positive association between MCPyV and cervical squamous cell carcinomas and adenocarcinomas.

Conclusions:

Current evidence does not support a role for MCPyV in the pathogenesis of cervical squamous cell carcinomas and adenocarcinomas.
Further research with larger sample sizes is recommended to definitively establish or refute this association.