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Tolfenamic acid in combination with caffeine: absorption during acute migraine
Methods and Findings in Experimental and Clinical Pharmacology
|October 1, 1985
Summary
Caffeine does not improve the absorption of tolfenamic acid during migraine attacks. Migraine itself appears to reduce drug absorption, and tolfenamic acid alone is effective for migraine relief.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Migraine Pathophysiology
Background:
- Tolfenamic acid is an anti-inflammatory analgesic for migraine.
- Caffeine is often included in analgesic formulations.
- The impact of caffeine on tolfenamic acid absorption during migraines is unknown.
Purpose of the Study:
- To investigate the effect of caffeine on the absorption of tolfenamic acid in migraine patients.
Main Methods:
- A crossover study design was employed.
- Migraine patients were administered tolfenamic acid with either caffeine or a placebo.
- Tolfenamic acid absorption and pain relief were monitored.
Main Results:
- Caffeine did not significantly alter the absorption of tolfenamic acid during migraine attacks.
- The extent of tolfenamic acid absorption was reduced during migraine attacks, irrespective of caffeine co-administration.
- Pain relief within five hours was not affected by caffeine.
Conclusions:
- The migraine condition itself impairs tolfenamic acid absorption.
- Caffeine does not counteract this reduced absorption.
- Tolfenamic acid monotherapy is sufficient for migraine treatment.