Chemotherapy Primary Dose Reduction in Older Cancer Patients: A Retrospective Cohort
Wafa Bouleftour1, Fabien Tinquaut2, Ludovic Lafaie3
1Institut de Cancérologie et d'Hématologie Universitaire de Saint-Étienne, CHU de Saint Etienne, Saint Etienne, France.
Abstract:
Primary dose reduction (PDR) in the first course of chemotherapy is an empirical practice, commonly used in older population. Patients over 70 years old receiving a first course of chemotherapy for a solid tumor were enrolled. A total of 179 patients were included. Standard dose was used in 69.8% of patients, while 30.2% received PDR of chemotherapy. Only 29.6% received a standardized geriatric assessment. Patients receiving standard doses presented 83.2% of toxicities, while 68% of toxicities were reported in patients receiving PDR. The toxicity rate was significantly decreased in patients treated with reduced first-cycle dose of chemotherapy.
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