Factors associated with risk analysis for asymptomatic left ventricular diastolic dysfunction in nondialysis patients...

Area of Science:

• Nephrology
• Cardiology
• Internal Medicine

Background:

• Heart failure (HF) is a significant predictor of outcomes in chronic kidney disease (CKD) patients.
• Left ventricular diastolic dysfunction (LVDD) is a common cause of HF with preserved ejection fraction (HFpEF) in CKD.
• Identifying risk factors for LVDD is crucial for managing cardiovascular disease (CVD) in CKD.

Purpose of the Study:

• To determine the prevalence of asymptomatic left ventricular diastolic dysfunction (ALVDD) in nondialysis CKD patients.
• To identify clinical and demographic factors associated with ALVDD in this population.

Main Methods:

• Retrospective cross-sectional study involving 339 nondialysis CKD patients.
• Collection of clinical and echocardiographic data.
• Multivariate logistic regression analysis to identify risk factors for ALVDD.

Main Results:

• A high prevalence of ALVDD (92.04%) was observed in the study cohort.
• Factors associated with increased risk for ALVDD include older age, diabetic nephropathy, hypertensive nephropathy, advanced CKD stage, elevated mean arterial pressure, and increased urinary protein.
• Low blood calcium was associated with a reduced risk of ALVDD.

Conclusions:

• Asymptomatic left ventricular diastolic dysfunction is highly prevalent in nondialysis CKD patients.
• Close monitoring and management of age, hypertension, diabetes, CKD progression, proteinuria, and calcium levels are essential.
• Early detection and intervention for ALVDD may help prevent progression to symptomatic HF and improve cardiovascular outcomes in CKD patients.