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Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences.
Charlotte E Sofield1, Ryan S Anderton1,2, Anastazja M Gorecki1
1School of Health Sciences, University of Notre Dame Australia, Fremantle, WA 6160, Australia.
Current Issues in Molecular Biology
|May 24, 2024
Summary
Microplastics from environmental pollution are ingested orally, potentially causing gut inflammation and dysfunction. Emerging evidence links these particles to neurodegenerative diseases via the gut-brain axis.
Area of Science:
- Environmental Science
- Toxicology
- Neuroscience
Background:
- Microplastic pollution is widespread, contaminating food and water.
- Oral ingestion is a primary human exposure route to microplastics.
- Microplastics may disrupt gut microbiota and cause inflammation.
Purpose of the Study:
- To review the effects of oral microplastic exposure on the gut-brain axis.
- To explore microplastic uptake, immune activation, and neurological effects.
- To assess the potential contribution of microplastics to neurodegenerative diseases.
Main Methods:
- Comprehensive narrative review of existing scientific literature.
- Analysis of studies on gastrointestinal uptake and disruption.
- Examination of evidence for immune, systemic, and neurological impacts.
Main Results:
- Microplastics are not inert and can induce gut dysbiosis and inflammation.
- Evidence suggests microplastics translocate from the gut to other body systems.
- Potential adverse effects on immune and nervous systems are indicated.
Conclusions:
- Oral microplastic exposure poses risks to gut health and potentially the brain.
- Microplastics may be a contributing factor to the rise in neurodegenerative diseases.
- Further research and policy changes are needed to mitigate risks.
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