The cellular immunology of myasthenia gravis

The possible role of the thymus in autosensitization to the acetylcholine receptor (AChR) in myasthenia gravis is briefly discussed, and work on autoantibody synthesis in vitro is reviewed. Whereas blood lymphocytes sometimes make anti-AChR in response to mitogens, spontaneous production is more regularly observed in cells from lymph nodes, bone marrow and, above all, thymus, where it is selectively activated. Cell separation studies imply a dominant contribution by the germinal centre cells and plasma cells there, many of which are autonomous (i.e. no longer require T cell help). The need for germinal centre-directed immunosuppressive regimes is discussed.