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Recent Advances in Aptamer-Based Biosensors for Bacterial Detection.
Vincent Léguillier1,2, Brahim Heddi2, Jasmina Vidic1
1INRAE, AgroParisTech, Micalis Institut, Université Paris-Saclay, UMR 1319, 78350 Jouy-en-Josas, France.
Biosensors
|May 24, 2024
Summary
Nucleic acid aptamers offer a versatile and cost-efficient method for detecting pathogenic bacteria. Aptasensors provide sensitive detection of bacteria, toxins, and biomarkers, improving infection treatment and contamination prevention.
Area of Science:
- Biotechnology
- Analytical Chemistry
- Molecular Biology
Background:
- Rapid and sensitive detection of pathogenic bacteria is crucial for infection control and treatment.
- Nucleic acid aptamers offer high affinity and specificity for bacterial targets.
- Aptamers integrated with various analytical techniques form versatile biosensors.
Purpose of the Study:
- To review the development and structural characterization of aptamers for bacterial detection.
- To highlight chemical modifications for enhanced aptamer performance.
- To discuss recent aptasensor applications and future perspectives.
Main Methods:
- Review of literature on aptamer development and aptasensor technology.
- Analysis of structural characteristics and chemical modifications of aptamers.
- Discussion of integrated analytical techniques (optical, electrochemical, mass-sensitive).
Main Results:
- Aptamers exhibit high affinity and specificity for bacterial cells, biomarkers, and toxins.
- Chemical modifications improve aptamer recognition and stability in biological samples.
- Aptasensors demonstrate sensitive and rapid detection capabilities.
Conclusions:
- Aptasensor technology shows significant promise for bacterial detection.
- Further research is needed to overcome barriers for widespread application.
- Aptamer-based detection contributes to timely infection prevention and treatment.
