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Ocular Tics and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)
Stefano Dore1,2, Daniele Satta1, Angelo Zinellu3
1Department of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy.
Diseases (Basel, Switzerland)
|May 24, 2024
Summary
Ocular tics are common in children with Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal infections (PANDAS). Higher anti-DNase B antibody titers may indicate ocular tic development, and antibiotics showed symptom improvement.
Area of Science:
- Ophthalmology
- Pediatric Neurology
- Infectious Diseases
Background:
- Ocular tics are not well-understood in Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal infections (PANDAS).
- This study investigates the prevalence and characteristics of ocular tics in children with PANDAS.
Purpose of the Study:
- To determine the frequency of ocular tics in children with motor tics.
- To explore the association between ocular tics and specific immunological markers in PANDAS patients.
- To evaluate the efficacy of antibiotic treatment for ocular tics in this population.
Main Methods:
- Retrospective analysis of clinical records from children with motor tics.
- Investigation of ocular tic presence and recording of immunological data (ASO, anti-DNase B, ESR, CRP).
- Comparison of immunological markers between children with and without ocular tics, including those diagnosed with PANDAS.
Main Results:
- Out of 40 children with motor tics, 33 (82.5%) exhibited ocular tics.
- Children with ocular tics showed significantly higher anti-DNase B antibody titers and CRP levels.
- A PANDAS diagnosis was made in 60% of cases, with higher anti-DNase B titers in PANDAS children with ocular tics.
- Antibiotic treatment led to significant symptom improvement or resolution in most patients.
Conclusions:
- Elevated anti-DNase B antibody titers may play a role in the development of ocular tics in PANDAS.
- Antibiotic therapy appears beneficial for managing ocular tics in children with PANDAS.
- Further research is warranted to validate these findings and elucidate the underlying mechanisms.
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