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Summary
Ampicillin-resistant Haemophilus influenzae strains were identified in sputum cultures. Cefuroxime, cefotaxime, and gentamicin showed effectiveness against these resistant bacteria.
Area of Science:
- Microbiology
- Infectious Diseases
- Antibiotic Resistance
Background:
- Haemophilus influenzae is a common cause of respiratory infections.
- Antibiotic resistance in H. influenzae poses a significant challenge to treatment.
- Monitoring local resistance patterns is crucial for effective antimicrobial therapy.
Purpose of the Study:
- To determine the prevalence of ampicillin resistance in Haemophilus influenzae isolated from sputum.
- To evaluate the in vitro susceptibility of ampicillin-resistant strains to alternative antibiotics.
Main Methods:
- Sputum samples were cultured to isolate Haemophilus influenzae strains.
- Ampicillin resistance was identified, with beta-lactamase production confirmed.
- Susceptibility testing was performed on resistant isolates using various antibiotics.
Main Results:
- 9.3% (14/150) of H. influenzae strains were ampicillin-resistant and beta-lactamase-producing.
- Cefuroxime, cefotaxime, gentamicin, and amoxicillin-clavulanic acid were effective alternatives.
- Tetracycline, trimethoprim, and co-trimoxazole showed usefulness, while erythromycin had limited utility.
Conclusions:
- A significant proportion of H. influenzae isolates exhibited ampicillin resistance.
- Several alternative antibiotics are effective against ampicillin-resistant strains.
- Judicious antibiotic selection is necessary for treating H. influenzae infections.