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The Prognostic Role of Serum β-Trace Protein Levels among Patients on Maintenance Hemodialysis
Po-Yu Huang1,2, Bang-Gee Hsu3,4, Chih-Hsien Wang3,4
1Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
Diagnostics (Basel, Switzerland)
|May 24, 2024
Summary
Beta-trace protein (BTP) can predict mortality in hemodialysis patients. Higher BTP levels and diabetes mellitus indicate a higher risk of death, highlighting BTP as a novel prognostic biomarker.
Area of Science:
- Nephrology
- Cardiology
- Biomarker Discovery
Background:
- Cardiovascular diseases are a leading cause of death in kidney failure patients.
- Beta-trace protein (BTP) indicates glomerular filtration and predicts cardiovascular events.
- The prognostic value of BTP in hemodialysis (HD) patients requires further investigation.
Purpose of the Study:
- To evaluate the prognostic significance of serum BTP levels in patients undergoing chronic hemodialysis.
- To determine if BTP can predict adverse outcomes and mortality in this population.
Main Methods:
- A cohort of 96 patients on chronic hemodialysis was enrolled.
- Baseline clinical data were collected, and patients were followed for 3 years.
- Serum BTP concentrations were measured and analyzed for correlation with mortality.
Main Results:
- Twenty-five out of 96 patients died within the 3-year follow-up period.
- Higher serum BTP concentrations and a higher incidence of diabetes mellitus (DM) were observed in non-survivors.
- Serum BTP levels above the median, presence of DM, and low serum albumin independently predicted survival.
Conclusions:
- Serum BTP is a novel and independent biomarker for predicting overall outcomes in patients undergoing hemodialysis.
- Elevated BTP levels may signify increased mortality risk in HD patients.
- BTP holds potential for risk stratification and management of cardiovascular outcomes in kidney disease.
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