Advanced Antimicrobial and Anti-Infective Strategies to Manage Peri-Implant Infection: A Narrative Review

Area of Science:

• Biomaterials Science
• Dental Implantology
• Infectious Disease

Background:

• Systemic antibiotic prophylaxis in implant dentistry, while reducing infection, is controversial due to antimicrobial resistance.
• Antimicrobial resistance poses significant health and economic burdens.
• Existing antibiotic use can lead to adverse effects.

Purpose of the Study:

• To review advanced biomaterial strategies for dental implants.
• Focus on anti-pathogenic and immune balance mechanisms.
• To reduce reliance on systemic antibiotics.

Main Methods:

• Review of literature on biomaterial strategies for implant components.
• Analysis of anti-pathogenic mechanisms.
• Analysis of immune balance mechanisms.

Main Results:

• Advanced biomaterial strategies offer alternatives to systemic antibiotics.
• Modifying dental implant surfaces is a key approach.
• Regulating early immune responses is crucial for prevention.

Conclusions:

• Biomaterial surface modification and immune regulation are promising for preventing peri-implant infections.
• These strategies may reduce the incidence of implant failure.
• A shift towards localized, mechanism-based prevention is recommended.