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Updated: Jun 25, 2025

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
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Targeting Inflammation and Oxidative Stress to Improve Outcomes in a TNBS Murine Crohn's Colitis Model

Anisha Apte1, James R Bardill2, Jimena Canchis1

  • 1Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Arizona Tucson College of Medicine, Banner Children's at Diamond Children's Medical Center, Tucson, AZ 85721, USA.

Nanomaterials (Basel, Switzerland)
|May 24, 2024
PubMed
Summary

Cerium oxide nanoparticles conjugated to microRNA 146a (CNP-miR146a) reduced inflammation and oxidative stress in a mouse model of Crohn's disease. This novel compound improved clinical outcomes and decreased inflammatory markers in colitis.

Keywords:
Crohn’s diseaseTNBScolitisinflammatory bowel diseasenanomedicine

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