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Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
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Correlation between the thyroid computed tomography value and thyroid function in hyperthyroidism: a retrospective

Haruna Iwanaga1,2, Naotoshi Fujita1, Shinji Abe1

  • 1Department of Radiological Technology, Nagoya University Hospital, Nagoya, Japan.

Annals of Nuclear Medicine
|May 24, 2024
PubMed
Summary

Computed tomography (CT) values correlate with the effective half-life (EHL) of radioiodine in hyperthyroid patients. This finding suggests CT values reflect thyroid function, particularly iodine discharge, aiding treatment assessment.

Keywords:
CT valueDiseaseEffective half-lifeGravesPlummer diseaseRadioiodine therapyThyroid

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Area of Science:

  • Endocrinology
  • Nuclear Medicine
  • Radiology

Background:

  • Radioiodine (I-131) therapy is a standard treatment for hyperthyroidism.
  • Understanding factors influencing I-131 therapy effectiveness is crucial for patient management.

Purpose of the Study:

  • To investigate the relationship between computed tomography (CT) values and thyroid gland function and volume in hyperthyroid patients.
  • To identify factors affecting CT values in hyperthyroidism.

Main Methods:

  • Retrospective analysis of 38 Graves' disease and 10 Plummer disease patients.
  • CT scans were used to determine mean thyroid gland CT value and volume.
  • Radioiodine uptake (RIU) and effective half-life (EHL) were assessed after I-131 administration.
  • Correlations between CT value and EHL, RIU, thyroid hormones (FT3, FT4, TSH), and TRAb levels were analyzed.

Main Results:

  • A significant positive correlation was found between CT value and EHL in both Graves' disease (r=0.62, p<0.0001) and Plummer disease (r=0.74, p<0.05) patients.
  • No significant correlation was observed between CT value and other assessed parameters.

Conclusions:

  • Thyroid CT value is significantly correlated with EHL, indicating it reflects thyroid function.
  • The CT value appears primarily related to factors influencing iodine discharge from the thyroid gland.