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mRNAome Analysis of Whole Blood of Patients with Psoriatic Arthritis, Ankylosing Spondylitis, and Rheumatoid Arthritis.

Current rheumatology reviews·2025
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Differences between psoriatic arthritis and psoriasis in multi-omics.

Siming Gao1,2, Hui Song3

  • 1Department of Rheumatology, Beijing Jishuitan Hospital, Guizhou Hospital, Guiyang, China.

Archives of Dermatological Research
|May 24, 2024
PubMed
Summary

This review synthesizes multi-omics data for psoriatic arthritis and psoriasis, highlighting disease distinctions and potential biomarkers for early diagnosis and treatment. It serves as a foundational reference for understanding psoriatic disease pathways.

Keywords:
DifferencesMulti-omicsPsoriasisPsoriatic arthritis

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Area of Science:

  • Dermatology and Immunology
  • Genetics and Molecular Biology

Background:

  • Psoriatic arthritis (PsA) and psoriasis are chronic inflammatory conditions with overlapping yet distinct pathologies.
  • Understanding their molecular underpinnings is crucial for effective management.

Purpose of the Study:

  • To conduct a systematic review of multi-omics data (genomics, transcriptomics, epigenetics, proteomics, metabonomics, microbiota) in PsA and psoriasis.
  • To elucidate the differences and shared pathways between these two diseases.
  • To identify potential biomarkers for earlier diagnosis and targeted therapies.

Main Methods:

  • Systematic literature review of omics studies.
  • Comparative analysis of genomic, transcriptomic, epigenetic, proteomic, metabonomic, and microbiota data.
  • Integration of multi-omics findings to understand disease pathogenesis.

Main Results:

  • Identification of distinct and overlapping molecular signatures between PsA and psoriasis across various omics layers.
  • Insights into key biological pathways implicated in the pathogenesis of both conditions.
  • Potential utility of identified molecular features as biomarkers for disease stratification and treatment selection.

Conclusions:

  • Multi-omics integration provides a comprehensive view of PsA and psoriasis pathogenesis.
  • Understanding these molecular differences is key to developing targeted diagnostic and therapeutic strategies.
  • This review serves as a reference for future research in psoriatic disease biomarker discovery.