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Updated: Jun 25, 2025

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
In-cell chemical construction of a photoswitchable CENP-E using a photochromic covalent inhibitor
Kazuya Matsuo1, Shusuke Yamaoka1, Tomonori Waku1
1Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan. kmatsuo@kit.ac.jp.
Abstract:
An arylazopyrazole-based covalent inhibitor targeting the mitotic motor protein of centromere-associated protein E (CENP-E) was developed. Using this photoswitchable inhibitor, a photoswitchable CENP-E was chemically constructed in cells, which enabled to local control of mitotic cell division with light illumination.
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