Plasma BDNF/Irisin Ratio Associates with Cognitive Function in Older People

Area of Science:

• Neuroscience
• Biomarkers
• Gerontology

Background:

• Reliable blood biomarkers are essential for early detection and treatment monitoring of cognitive impairment, including Alzheimer's disease.
• Mild cognitive impairment (MCI) affects a significant portion of the aging population, necessitating accurate diagnostic tools.

Purpose of the Study:

• To investigate differences in plasma biomarkers between individuals with MCI and cognitively normal older adults.
• To explore the relationship between plasma biomarkers, their ratios, and cognitive performance.

Main Methods:

• A cross-sectional study involving 250 older adults (124 with MCI, 126 cognitively normal).
• Measurement of plasma brain-derived neurotrophic factor (BDNF), irisin, and clusterin.
• Assessment of global cognition using the Montreal Cognitive Assessment.

Main Results:

• Plasma irisin levels were significantly different between MCI and control groups, with higher concentrations associated with increased MCI probability.
• Plasma BDNF concentration correlated with cognitive performance, while the BDNF/irisin ratio was associated with both lower MCI risk and better cognitive function.
• No significant association was found for clusterin levels.

Conclusions:

• The plasma BDNF/irisin ratio may serve as a reliable indicator for assessing MCI presence and cognitive performance.
• Further research into BDNF and irisin as biomarkers for cognitive health is warranted.