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Helicobacter pylori Infection in Children With Cerebral Palsy: A Cross-Sectional Study
Sally M Ismael1, Dina S Atia1, Salwa A Atlam1
1Faculty of Medicine, Pediatric Department, Tanta University Hospital, Tanta, Egypt.
Insights
Helicobacter pylori infection is common in children with cerebral palsy (CP). Risk factors include intellectual disability and poor eating ability, leading to more gastrointestinal issues.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Gastroenterology
Background:
- Children with cerebral palsy (CP) often experience co-occurring conditions, including gastrointestinal problems.
- Helicobacter pylori (H. pylori) infection is a prevalent global issue linked to various gastrointestinal symptoms.
Purpose of the Study:
- To determine the prevalence of H. pylori infection in pediatric patients diagnosed with cerebral palsy.
- To identify risk factors and associated gastrointestinal manifestations of H. pylori in children with CP.
Main Methods:
- A cross-sectional study involving 100 children (aged 2-17 years) with CP was conducted over eight months.
- H. pylori stool antigen was detected using enzyme-linked immunosorbent assay (ELISA).
Main Results:
- The prevalence of H. pylori infection was 45% among the studied children with CP.
- Intellectual disability, low socioeconomic status, semisolid diet, and severe eating/drinking difficulties (EDACS levels 4-5) were significant predictors of H. pylori infection.
- H. pylori-positive children with CP exhibited higher incidences of vomiting, abdominal pain, and gastrointestinal bleeding.
Conclusions:
- H. pylori infection is a common comorbidity in children with cerebral palsy.
- Key risk factors for H. pylori infection in this population include intellectual disability, low socioeconomic status, and impaired oral intake.
- H. pylori infection exacerbates gastrointestinal problems in children with CP.
Background:
Children with cerebral palsy (CP) frequently have associated disorders and complications, including gastrointestinal problems. Helicobacter pylori is a common infection worldwide, frequently associated with gastrointestinal manifestations.
Methods:
To estimate the prevalence of H. pylori infection in children with CP, a cross-sectional study over an eight-month period was performed in the pediatric neurology outpatient clinic of Tanta University Hospital. The study included 100 patients with CP aged two to 17 years. All patients were tested for H. pylori antigen in stool by enzyme-linked immunosorbent assay.
Results:
The mean age of studied children with CP was 7.03 ± 4.1 years; there were 57 males and 43 females. Spastic quadriplegic CP was the most common type of CP (34%). Forty-five children with CP were positive for H. pylori antigen in stool. Intellectual disability (ID), low sociodemographic scoring system, semisolid diet, and Eating and Drinking Ability Classification System (EDACS) levels 4 and 5 were significant predictors of H. pylori infection (odds ratio of 1.86, 2.63, 12, and 1.77, respectively, P < 0.05). Vomiting, abdominal pain, and gastrointestinal tract bleeding were significantly more frequent in H. pylori-infected children with CP than noninfected children with CP (P value < 0.05) CONCLUSION: H. pylori is a relatively common infection among children with CP. The main risk factors for H. pylori infection were low socioeconomic level, ID, semisolid diet, and EDACS levels 4 and 5.
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