Exploring Causal Relationships between Circulating Inflammatory Proteins and Thromboangiitis Obliterans: A Mendelian
Bihui Zhang1, Rui He2, Ziping Yao1
1Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing, China.
Thrombosis and Haemostasis
|May 24, 2024
Summary
This study used Mendelian randomization to explore inflammatory proteins and Thromboangiitis Obliterans (TAO). Higher C-C motif chemokine 4 and glial cell line-derived neurotrophic factor levels may reduce TAO risk, while C-C motif chemokine 23 might increase it.
Area of Science:
- Genetics
- Immunology
- Vascular Biology
Background:
- Thromboangiitis obliterans (TAO) is a vascular disease with unknown causes and poor outcomes.
- Investigating genetic links to inflammatory proteins may reveal TAO's etiology.
Purpose of the Study:
- To determine the causal effect of circulating inflammatory proteins on Thromboangiitis Obliterans (TAO) using Mendelian randomization.
- To identify potential biomarkers for TAO risk and protection.
Main Methods:
- Mendelian randomization (MR) analysis integrating GWAS data for 91 inflammation-related proteins with TAO data.
- Utilized inverse variance weighting, MR-Egger, weighted median, MR-PRESSO, and multivariable MR (MVMR).
Main Results:
- Elevated C-C motif chemokine 4 (OR: 0.44) and glial cell line-derived neurotrophic factor (OR: 0.43) were associated with reduced TAO risk.
- Increased C-C motif chemokine 23 (OR: 1.88) showed a suggestive link to higher TAO risk.
- Sensitivity analyses confirmed no significant heterogeneity or pleiotropy.
Conclusions:
- C-C motif chemokine 4 and glial cell line-derived neurotrophic factor may serve as protective biomarkers for TAO.
- C-C motif chemokine 23 is a potential risk biomarker for TAO.
- Findings suggest causal links between these proteins and TAO pathogenesis, informing future therapeutic strategies.
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