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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

7.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Prodrugs01:30

Prodrugs

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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
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Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
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Drug Biotransformation: Overview01:16

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Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
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Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
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Updated: Jun 25, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

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An overview to drug repurposing.

Khushal Khambhati1, Abdulrahman H Alessa2, Vijai Singh1

  • 1Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, India.

Progress in Molecular Biology and Translational Science
|May 24, 2024
PubMed
Summary
This summary is machine-generated.

Drug repurposing offers a faster, cheaper alternative to developing new medications. This approach utilizes existing FDA-approved drugs for new therapeutic applications, accelerating drug discovery and disease treatment.

Keywords:
Drug discoveryDrug repurposingEfficacyMultidrug-resistantToxicityUSFDA

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Area of Science:

  • Pharmacology
  • Drug Discovery
  • Medicinal Chemistry

Background:

  • Developing novel drugs is a lengthy, costly process with significant market entry challenges.
  • Thousands of expired US Food and Drug Administration (USFDA) approved drug licenses present an opportunity for repurposing.
  • Drug repurposing provides a viable strategy to reduce the time, cost, and complexity of drug development.

Purpose of the Study:

  • To outline the key steps in traditional drug discovery.
  • To detail the process and benefits of drug repurposing.
  • To highlight existing repurposed drugs for bacterial, fungal, and viral diseases.

Main Methods:

  • Review of traditional drug discovery pipelines.
  • Analysis of drug repurposing methodologies.
  • Compilation of case studies on repurposed drugs for infectious diseases.

Main Results:

  • Drug repurposing significantly shortens development timelines and reduces costs compared to de novo drug discovery.
  • Identified several classes of repurposed drugs effective against various microbial infections.
  • Demonstrated the potential of leveraging existing pharmaceutical assets for emerging health threats.

Conclusions:

  • Drug repurposing is a powerful strategy to accelerate the availability of treatments.
  • Repurposing existing drugs can effectively combat bacterial, fungal, and viral diseases.
  • Unlocking the potential of established drugs is crucial for efficient drug discovery and outbreak management.