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Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Related Experiment Video

Updated: Jun 25, 2025

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets

Published on: February 23, 2024

Current progress in high-throughput screening for drug repurposing.

Khushal Khambhati¹, Deepak Siruka¹, Suresh Ramakrishna²

¹Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, India.

Progress in Molecular Biology and Translational Science

|May 24, 2024

Summary

This summary is machine-generated.

High-throughput screening (HTS) accelerates drug discovery by rapidly identifying active compounds. This technology, including microfluidics and organ-on-chip systems, is vital for cost-effective drug repurposing, particularly for bacterial infections and cancer.

Keywords:

Drug discovery Drug repurposing High throughput screening Lab-on-chip Microfluidics

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Area of Science:

Biotechnology and Pharmaceutical Sciences
Drug Discovery and Development

Background:

Conventional drug discovery is time-consuming and expensive.
Drug repurposing offers a cost-effective alternative with known toxicity profiles.
High-throughput screening (HTS) is crucial for identifying active compounds efficiently.

Purpose of the Study:

To highlight High-throughput screening (HTS) technologies for drug repurposing.
To discuss the application of HTS in accelerating drug discovery.
To showcase HTS for treating bacterial infections and cancer.

Main Methods:

Review of HTS technologies: microplate, microfluidics, lab-on-chip, and organ-on-chip.
Exploration of HTS applications in drug repurposing strategies.
Analysis of HTS utility in combating bacterial infections and cancer.

Main Results:

HTS provides a rapid and cost-effective method for compound screening.
Advanced HTS platforms like microfluidics and organ-on-chip enhance drug repurposing efficiency.
HTS demonstrates significant potential in addressing bacterial infections and cancer.

Conclusions:

HTS technologies are pivotal for modernizing pharmaceutical and biotechnology research.
Drug repurposing, enhanced by HTS, significantly speeds up the drug discovery pipeline.
The application of HTS in treating bacterial infections and cancer shows promising outcomes.