Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Standardizing Global Pediatric Stroke Pathways: Insights From a Global Survey Conducted by the Society of Neurointerventional Surgery Pediatric Special Interest Group.

Stroke (Hoboken, N.J.)·2026

Same author

Percutaneous and Endovascular Treatment of Spontaneous Intracranial Hypotension and Related Cerebrospinal Fluid Disorders.

Seminars in roentgenology·2026

Same author

Multi-dimensional MRI representation and privileged learning approaches to functional outcome prediction for ischemic stroke patients.

NPJ digital medicine·2026

Same author

Diagnostic cerebral angiography: A report of the SNIS Standards and Guidelines Committee, endorsed by ANZSNR and ESMINT.

Journal of neurointerventional surgery·2026

Same author

Peroxiredoxins in Stroke: Friends and Foes.

Cells·2026

Same author

Intelligent histology for tumor neurosurgery.

Neuro-oncology advances·2026

Same journal

Multidimensional Safety Assessment of a Low-Intensity Scanning Ultrasound (SUS) Protocol in Sheep.

Ultrasound in medicine & biology·2026

Same journal

Acoustic Characterization of a Modified IEC Agar-Based Tissue-Mimicking Material Across the 3.5-50 MHz Frequency Range.

Ultrasound in medicine & biology·2026

Same journal

Deep Learning-Based Standard Section Recognition and Multi-Organ Segmentation in Upper Abdominal Ultrasound.

Ultrasound in medicine & biology·2026

Same journal

Cardiac Natural Mechanical Wave Detection and Speed Estimation Using Deep Learning-Based 2-D Ultrasound Imaging: A Feasibility Study.

Ultrasound in medicine & biology·2026

Same journal

Region-Specific Evaluation of Plaque Segmentation in Cross-sectional Projections of Carotid Ultrasound Images Using Deep Learning Models in a Sub-clinical Atherosclerosis Cohort.

Ultrasound in medicine & biology·2026

Same journal

Simulating the Dedifferentiation Process of Thyroid Cancer: Insights from Mouse Models and Ultrasound Imaging.

Ultrasound in medicine & biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 25, 2025

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia

Published on: May 6, 2016

Neuronavigation-Guided Transcranial Histotripsy (NaviTH) System.

Sang Won Choi¹, Mahmoud Komaiha¹, Dave Choi¹

¹Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Ultrasound in Medicine & Biology

|May 24, 2024

Summary

This summary is machine-generated.

The first neuronavigation-guided transcranial histotripsy (NaviTH) system was developed for non-invasive brain ablation. Initial tests in human cadavers showed promising results, with targeting errors reduced to 2.5 mm after system improvements.

Keywords:

Brain Histotripsy Neuronavigation guidance Transcranial

More Related Videos

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Published on: July 16, 2020

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

Related Experiment Videos

Last Updated: Jun 25, 2025

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia

Published on: May 6, 2016

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Published on: July 16, 2020

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

Area of Science:

Neurosurgery
Medical Devices
Acoustic Medicine

Background:

Transcranial histotripsy offers a non-invasive approach for brain tissue ablation.
Accurate targeting is crucial for effective and safe transcranial procedures.
Existing neuronavigation systems require adaptation for transcranial applications.

Purpose of the Study:

To develop the first neuronavigation-guided transcranial histotripsy (NaviTH) system.
To establish an associated workflow for transcranial ablation procedures.
To investigate and characterize targeting errors in the NaviTH system.

Main Methods:

A 360-element transcranial histotripsy array was integrated with a clinical neuronavigation system.
A workflow including patient-to-array co-registration and pre-treatment aberration correction was developed.
The system was tested in human cadavers and excised human skullcaps to assess targeting accuracy.

Main Results:

The NaviTH system successfully created ablations in cadaver brains, confirmed by MRI.
Initial targeting errors were significant but reduced to 2.5 mm after workflow and instrument improvements.
Skull-induced focal shifts were minimized to 0.3 mm with aberration correction.

Conclusions:

The feasibility of the NaviTH system in a human cadaver model was demonstrated.
The system shows potential for transcranial histotripsy without active MRI guidance.
Further improvements are needed to enhance targeting accuracy for clinical application.