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Updated: Jun 25, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Gapless biosynthetic pathway enables sustainable paclitaxel production
Chengfeng Xue1, Meng Zhang1, Ruifeng Yao1
1State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410082, China; Yuelushan Laboratory, Changsha 410082, China; Greater Bay Area Institute for Innovation, Hunan University, Guangzhou 511300, China; Shenzhen Research Institute, Hunan University, Shenzhen 518000, China.
Abstract:
A recent leading-edge study by Jiang et al. identified two enzymes that are responsible for key reactions in the biosynthesis of baccatin III. The authors successfully reconstructed the baccatin III synthesis pathway with a minimal number of synthetic enzymes in tobacco leaves, laying the foundation for industrial-scale sustainable production of the anticancer drug paclitaxel.

