Related Experiment Video
Updated: Jun 25, 2025
12:52
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
15.8K
Constitutive type-1 interferons signaling activity in malignant gliomas
Chunzhao Li1,2, Lang Long1,2, Yi Wang1,2,3
1Department of Neurosurgery, Fengtai District, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Lu 119, Beijing, 100070, China.
Journal of Neuro-Oncology
|May 24, 2024
Summary
Constitutive Type-1 interferon (IFN-I) signaling is heterogeneous in gliomas, predicting poor outcomes and increased inflammation. Its activity varies by subtype and malignancy grade.
Area of Science:
- Neuro-oncology
- Immunology
- Cancer biology
Background:
- Constitutive Type-1 interferon (IFN-I) signaling shows a pro-tumor effect in various cancers.
- The role and heterogeneity of IFN-I signaling in gliomas are not well understood.
Purpose of the Study:
- To investigate the heterogeneity and clinical significance of constitutive IFN-I production and signaling in gliomas.
Main Methods:
- Multiplex immunofluorescence (mIF) on 364 gliomas.
- Bioinformatic analysis of TCGA and CGGA databases.
Main Results:
- IFN-I signaling is heterogeneous across glioma subtypes, increasing with malignancy grade and decreasing with IDH mutations.
- High IFN-I activity predicts unfavorable outcomes and correlates with glioma-associated inflammation.
- IFN-I signaling patterns in the glioma microenvironment (GME) are subtype-specific and predict overall survival.
Conclusions:
- Constitutive IFN-I signaling activity is a significant factor in glioma heterogeneity.
- It serves as a potential indicator of increased glioma inflammation and poor clinical prognosis.
More Related Videos
Related Concept Videos
01:17Intracellular Signaling Affects Focal Adhesions
2.7K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
2.7K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
01:20The JAK-STAT Signaling Pathway
8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.8K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
01:16TGF - β Signaling Pathway
7.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.3K