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Wogonin Inhibits Colorectal Cancer Proliferation and Epithelial Mesenchymal Transformation by Suppressing

Yujing Liu1,2, Lu Lu1,2, Peiqiu Cheng1

  • 1Institute of Digestive Diseases, Longhua Hospital, China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P. R. China.

The American Journal of Chinese Medicine
|May 25, 2024
PubMed

Insights

Wogonin, a compound from traditional Chinese medicine, effectively inhibits colorectal cancer growth and spread by targeting the AKT signaling pathway. This discovery offers a promising new therapeutic strategy for colorectal cancer treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products

Background:

  • Colorectal cancer (CRC) is a major global health concern and the third leading cause of cancer mortality.
  • Existing therapies for CRC require improvement, necessitating the identification of novel therapeutic agents.
  • Wogonin, a flavonoid derived from *Scutellaria baicalensis*, exhibits potential antitumor properties.

Purpose of the Study:

  • To investigate the inhibitory effects of wogonin on colorectal cancer proliferation, invasion, and metastasis.
  • To elucidate the underlying molecular mechanism of wogonin's antitumor activity in colorectal cancer.

Main Methods:

  • Utilized a phosphorylated protein microarray to analyze signaling pathway phosphorylation in colorectal cancer cells.
  • Conducted *in vitro* and *in vivo* experiments to validate wogonin's efficacy and mechanism of action.
  • Assessed the impact of wogonin on colorectal cancer cell proliferation, invasion, and metastasis.

Main Results:

  • Wogonin significantly suppressed colorectal cancer cell proliferation, invasion, and metastasis.
  • Wogonin intervention markedly reduced the phosphorylation of the AKT protein in colorectal cancer cells.
  • Confirmed that wogonin exerts its antitumor effects by inhibiting AKT pathway phosphorylation.

Conclusions:

  • Wogonin demonstrates significant antitumor activity against colorectal cancer.
  • The mechanism involves the inhibition of AKT protein phosphorylation.
  • Wogonin represents a potential new pharmacological treatment for colorectal cancer by targeting the AKT pathway.
Keywords:
AKTColorectal CancerEMTPhosphorylationScutellaria baicalensisWogonin

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