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Updated: May 6, 2026
Precision Measurements and Parametric Models of Vertebral Endplates
Published on: September 17, 2019
Morphology and Composition of Lumbar Intervertebral Discs: Comparative Analyses of Manual Measurement and
Yiting Cheng1, Yuyan Ma2, Kang Li3
1School of Mechanical Engineering, Sichuan University, Chengdu 610000, China.
Background:
The morphology and internal composition, particularly the nucleus-to-cross sectional area (NP-to-CSA) ratio of the lumbar intervertebral discs (IVDs), is important information for finite element models (FEMs) of spinal loadings and biomechanical behaviors, and, yet, this has not been well investigated and reported.
Methods:
Anonymized MRI scans were retrieved from a previously established database, including a total of 400 lumbar IVDs from 123 subjects (58 F and 65 M). Measurements were conducted manually by a spine surgeon and using two computer-assisted segmentation algorithms, i.e., fuzzy C-means (FCM) and region growing (RG). The respective results were compared. The influence of gender and spinal level was also investigated.
Results:
Ratios derived from manual measurements and the two computer-assisted algorithms (FCM and RG) were 46%, 39%, and 38%, respectively. Ratios derived manually were significantly larger.
Conclusions:
Computer-assisted methods provide reliable outcomes that are traditionally difficult for the manual measurement of internal composition. FEMs should consider the variability of NP-to-CSA ratios when studying the biomechanical behavior of the spine.
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