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Updated: May 11, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
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Congenital Vascular Malformations in Children: From Historical Perspective to a Multidisciplinary Approach in the

Frédérique C M Bouwman1,2,3, Bas H Verhoeven1,3, Willemijn M Klein2,3

  • 1Department of Pediatric Surgery, Amalia Children's Hospital, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Children (Basel, Switzerland)
|May 25, 2024
PubMed

Insights

Congenital vascular malformations (CVMs) arise from abnormal embryonic development. Recent advances in genetic identification and personalized treatments are improving patient care and well-being.

Area of Science:

  • Vascular Biology
  • Developmental Biology
  • Genetics

Background:

  • Congenital vascular malformations (CVMs) are present at birth due to aberrant embryogenesis.
  • Symptoms like pain, bleeding, and ulcers vary based on the affected vessels.
  • Treatment options are diverse, including conservative management, surgery, sclerotherapy, embolization, and pharmacotherapy.

Purpose of the Study:

  • To provide an overview of diagnostic and classification advancements in CVMs.
  • To highlight innovations in identifying genetic mutations and developing personalized treatments.
  • To emphasize the importance of a multidisciplinary approach for optimizing CVM patient care.

Main Methods:

  • Literature review focusing on historical developments and recent innovations in CVM diagnosis and treatment.
  • Analysis of key genetic discoveries and their impact on personalized medicine.
  • Discussion of multidisciplinary care strategies.

Main Results:

  • Significant progress has been made in understanding the genetic basis of CVMs.
  • Personalized treatment strategies are emerging based on genetic findings.
  • A multidisciplinary approach is crucial for comprehensive patient management.

Conclusions:

  • Advances in genetics and personalized medicine are transforming CVM care.
  • Optimizing clinical outcomes requires a holistic approach addressing physical and psychosocial well-being.
  • Continued research and collaboration are essential for improving the management of these rare conditions.

Keywords:
arteriovenous malformationscongenital vascular malformationshealth-related quality of lifelymphatic malformationspediatric surgerysclerotherapysirolimusvenous malformations

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