Related Experiment Video
Updated: Jun 28, 2026

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes hPSC-CMs Using Multi-electrode Arrays MEAs
Published on: May 12, 2017
Congenital Long QT Syndrome in Children and Adolescents: A General Overview
Elia Balestra1, Marco Bobbo2, Marco Cittar3
1Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy.
Abstract:
Congenital long QT syndrome (LQTS) represents a disorder of myocardial repolarization characterized by a prolongation of QTc interval on ECG, which can degenerate into fast polymorphic ventricular arrhythmias. The typical symptoms of LQTS are syncope and palpitations, mainly triggered by adrenergic stimuli, but it can also manifest with cardiac arrest. At least 17 genotypes have been associated with LQTS, with a specific genotype-phenotype relationship described for the three most common subtypes (LQTS1, -2, and -3). β-Blockers are the first-line therapy for LQTS, even if the choice of the appropriate patients needing to be treated may be challenging. In specific cases, interventional measures, such as an implantable cardioverter-defibrillator (ICD) or left cardiac sympathetic denervation (LCSD), are useful. The aim of this review is to highlight the current state-of-the-art knowledge on LQTS, providing an updated picture of possible diagnostic algorithms and therapeutic management.
Related Concept Videos
Nature and Nurture
Signs of Puberty
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Socioemotional Development during Infancy
Primary Temperament Types
Stella Chess...
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Conduct Disorder

