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Updated: Jun 25, 2025

Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks
Qing Meng1,2, Chun-Hsien Su3,4
1School of Physical Education, Huaqiao University, Xiamen 361021, China.
Abstract:
This review comprehensively evaluates the effects of physical exercise on oxidative and nitrosative stress, mainly focusing on the role of antioxidants. Using a narrative synthesis approach, data from empirical studies, reviews, systematic reviews, and meta-analyses published between 2004 and 2024 were collated from databases like PubMed, EBSCO (EDS), and Google Scholar, culminating in the inclusion of 41 studies. The quality of these studies was rigorously assessed to ensure the clarity of objectives, coherence in arguments, comprehensive literature coverage, and depth of critical analysis. Findings revealed that moderate exercise enhances antioxidant defenses through hormesis, while excessive exercise may exacerbate oxidative stress. The review also highlights that while natural dietary antioxidants are beneficial, high-dose supplements could impede the positive adaptations to exercise. In conclusion, the review calls for more focused research on tailored exercise and nutrition plans to further understand these complex interactions and optimize the health outcomes for athletes and the general population.
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