Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunological interference of high dose corticosteroids.

M Heideman, A Bengtsson

    Acta Chirurgica Scandinavica. Supplementum
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Observation of disorder-free localization using a (2+1)D lattice gauge theory on a quantum processor.

    Science (New York, N.Y.)·2026
    Same author

    Clinical and histopathological features of a population-based cohort of 95 consecutive patients with immunoglobulin G4-related disease in Stockholm, Sweden, during a five-year period.

    Scandinavian journal of rheumatology·2026
    Same author

    Visualizing dynamics of charges and strings in (2 + 1)D lattice gauge theories.

    Nature·2025
    Same author

    Scaling and logic in the colour code on a superconducting quantum processor.

    Nature·2025
    Same author

    Thermalization and criticality on an analogue-digital quantum simulator.

    Nature·2025
    Same author

    Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms.

    BMC rheumatology·2025

    High-dose corticosteroids (HDC) suppress immune cells and reduce lymphoid tissue. While beneficial in acute conditions like septic shock, prolonged HDC use can lead to severe immune dysfunction and complications.

    Area of Science:

    • Immunology
    • Pharmacology

    Background:

    • High-dose corticosteroids (HDC) are potent immunomodulators.
    • Their effects on cellular and humoral immunity are significant.
    • Understanding these effects is crucial for clinical applications.

    Purpose of the Study:

    • To detail the impact of HDC on immune system components.
    • To elucidate the mechanisms behind HDC's immunosuppressive effects.
    • To discuss the clinical implications of HDC in acute and chronic conditions.

    Main Methods:

    • Review of existing literature on corticosteroid effects on immune cells.
    • Analysis of changes in lymphoid tissue size and cellular function.
    • Examination of humoral immune factor alterations.

    Related Experiment Videos

    Main Results:

    • HDC reduces lymphoid tissue size and weight.
    • Impaired lymphocyte function, including reduced B- and T-lymphocyte synthesis.
    • Decreased immunoglobulin levels and impaired antibody-complement binding.
    • Reduced T-cell responsiveness and impaired leukocyte migration.
    • Inhibition of humoral factors like complement activation, chemotaxis, and phagocytosis.

    Conclusions:

    • HDC profoundly impacts both cellular and humoral immunity.
    • Beneficial effects observed in acute inflammatory conditions (e.g., septic shock, transplant rejection).
    • Potential for severe immune suppression and complications with prolonged use.