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RETRACTED: High PGC-1α Expression as a Poor Prognostic Indicator in Intracranial Glioma
Yu-Wen Cheng1,2, Jia-Hau Lee3, Chih-Hui Chang4
1Department of Neurosurgery, Kaohsiung Veterans General Hospital, Kaohsiung 807, Taiwan.
Biomedicines
|May 25, 2024
Summary
High expression of Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) correlates with advanced glioma stages and poor survival. Downregulating PGC-1α inhibits tumor progression, suggesting it as a therapeutic target for brain tumors.
Area of Science:
- Neuro-oncology
- Cancer Metabolism
- Molecular Biology
Background:
- Gliomas are common adult primary brain tumors with limited survival improvements.
- Few prognostic biomarkers exist for malignant glioma.
- Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) regulates cancer metabolism and cell adaptation.
Purpose of the Study:
- To evaluate the clinicopathological roles of PGC-1α in glioma.
- To explore the functions of PGC-1α in glioma progression.
Main Methods:
- Immunohistochemistry
- Cell culture
- siRNA transfection
- Cell viability assays
- Western blot analyses
- In vitro and in vivo invasion and migration assays.
Main Results:
- High PGC-1α expression is linked to advanced glioma pathological stage and reduced overall survival.
- Downregulation of PGC-1α suppressed glioma cell proliferation, invasion, and migration.
- Altered expression of oncogenic markers was observed upon PGC-1α downregulation.
Conclusions:
- PGC-1α is critical for maintaining the malignant phenotype of glioma cells.
- Targeting PGC-1α may offer an effective strategy to inhibit glioma progression.
- Targeting PGC-1α could improve patient survival outcomes in glioma.
