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Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
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PROTACs in Ovarian Cancer: Current Advancements and Future Perspectives
Makenzie Vorderbruggen1,2, Carlos A Velázquez-Martínez3, Amarnath Natarajan1,2
1Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA.
International Journal of Molecular Sciences
|May 25, 2024
Summary
Targeted protein degradation (TPD) using proteolysis-targeting chimeras (PROTACs) offers a novel therapeutic strategy for ovarian cancer. This review explores PROTACs in ovarian cancer models and discusses strategies for selective delivery and improved efficacy.
Area of Science:
- Oncology
- Molecular Biology
- Drug Discovery
Background:
- Ovarian cancer is a leading cause of gynecologic cancer mortality.
- Advanced ovarian cancer frequently relapses, with current therapies often lacking curative potential.
- Novel therapeutic strategies are urgently needed for ovarian cancer treatment.
Purpose of the Study:
- To review proteolysis-targeting chimeras (PROTACs) investigated in ovarian cancer models.
- To highlight PROTACs from other cancers with potential ovarian cancer applications.
- To discuss advancements in selective delivery and pharmacodynamics of PROTACs for ovarian cancer.
Main Methods:
- Literature review of PROTACs in ovarian cancer research.
- Analysis of PROTACs studied in other cancer types for potential ovarian cancer utility.
- Exploration of strategies for targeted delivery and improved pharmacodynamics.
Main Results:
- Synopsis of current PROTACs tested in ovarian cancer models.
- Identification of promising PROTAC candidates from other malignancies.
- Discussion of enabling technologies for PROTACs in ovarian cancer.
Conclusions:
- PROTACs represent a promising targeted protein degradation approach for ovarian cancer.
- Further research into selective delivery and optimized pharmacodynamics is crucial for clinical translation.
- PROTACs hold potential to overcome limitations of existing ovarian cancer therapies.
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