Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Osteopetrosis].

M L Labat

    Annales De Biologie Clinique
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Osteopetrosis, a bone disease, is linked to immune system deficiencies in animal models. Research highlights the connection between immune cells like T lymphocytes and macrophages and bone regeneration processes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Stem cells and the promise of eternal youth: embryonic versus adult stem cells.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2001
    Same author

    Regulation by phagic T-lymphocytes of a (pluripotent?) organ stem cell present in adult human blood. A beneficial exception to self-tolerance.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2001
    Same author

    On the track of a human circulating mesenchymal stem cell of neural crest origin.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2000
    Same author

    Possible retroviral origin of prion disease: could prion disease be reconsidered as a preleukemia syndrome?

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·1999
    Same author

    Possible retroviral etiology of human breast cancer.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·1998
    Same author

    Possible retroviral origin of prion diseases.

    Medical hypotheses·1998
    Same journal

    [The role of the heart-on-a-chip to drug evaluation].

    Annales de biologie clinique·2026
    Same journal

    A morphology-driven proof-of-concept study linking interphase nuclear abnormalities to dicentric-mediated genomic instability.

    Annales de biologie clinique·2026
    Same journal

    Analytical validation and clinical concordance of Diazyme free light chain assays on the Cobas® platform compared with Freelite™.

    Annales de biologie clinique·2026
    Same journal

    Small-cell secondary plasma cell leukemia mimicking low-grade B-cell lymphoma.

    Annales de biologie clinique·2026
    Same journal

    [Multiple myeloma and analytical discrepancy in serum free light chain assay: a case report].

    Annales de biologie clinique·2026
    Same journal

    [Summary of the 34th National Conference of the National College of Hospital Biochemistry].

    Annales de biologie clinique·2026
    See all related articles

    Area of Science:

    • Immunology
    • Bone Biology
    • Pathology

    Context:

    • Osteopetrosis is characterized by impaired osteoclast function, leading to bone density abnormalities.
    • Animal models, including op/op mutant rats and Cl2MDP-induced models, offer insights into osteopetrosis pathogenesis.
    • These models reveal a strong association between immune system dysregulation and skeletal pathology.

    Purpose:

    • To investigate the immunological underpinnings of osteopetrosis.
    • To explore the role of immune deficiencies in the development of osteopetrosis.
    • To elucidate the relationship between immune cells and bone regeneration.

    Summary:

    • Animal models of osteopetrosis demonstrate a link to immune deficiencies, affecting T lymphocyte responses and macrophage differentiation.

    Related Experiment Videos

  • Specifically, Cl2MDP treatment in mice inhibits thymus-dependent macrophage differentiation, a key process in bone remodeling.
  • These findings underscore the intricate interplay between the immune and skeletal systems in osteopetrosis.

    • Impact:

    • Establishes osteopetrosis as an immune-related condition.
    • Provides a basis for understanding the immune system's role in bone diseases.
    • Facilitates research into therapeutic strategies targeting immune pathways for osteopetrosis treatment.