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Published on: September 20, 2024
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Long Non-Coding RNAs in Sjögren's Disease
Ondřej Pastva1,2, Kerstin Klein1,2
1Department of Rheumatology and Immunology, Inselspital, Bern University Hospital, University of Bern, 3008 Bern, Switzerland.
International Journal of Molecular Sciences
|May 25, 2024
Summary
Long, non-coding RNAs (lncRNAs) show aberrant expression in Sjögren's disease (SjD), a condition causing dryness and fatigue. This review explores lncRNAs' roles in SjD, including immune regulation and potential as biomarkers.
Area of Science:
- Immunology
- Genetics
- Molecular Biology
Background:
- Sjögren's disease (SjD) is an autoimmune disorder causing mucosal dryness, fatigue, and pain.
- Key features include salivary/lacrimal gland inflammation, auto-antibodies, and extra-glandular issues.
- Aberrant expression of long, non-coding RNAs (lncRNAs) is noted in autoimmune diseases, including SjD.
Purpose of the Study:
- To review current literature on lncRNAs in Sjögren's disease.
- To explore the role of lncRNAs in SjD pathogenesis.
- To identify the potential of lncRNAs as biomarkers for SjD.
Main Methods:
- Literature review of studies on lncRNAs and Sjögren's disease.
- Analysis of lncRNA involvement in immune regulation.
- Investigation of lncRNA functions in X chromosome inactivation.
Main Results:
- lncRNAs are aberrantly expressed in Sjögren's disease.
- lncRNAs play roles in immune modulation and X chromosome inactivation.
- lncRNAs show potential as diagnostic or prognostic biomarkers for SjD.
Conclusions:
- lncRNAs are implicated in the pathogenesis of Sjögren's disease.
- Further research into lncRNAs could lead to novel SjD diagnostic and therapeutic strategies.
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