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Chemotherapy-Induced Changes in Plasma Amino Acids and Lipid Oxidation of Resected Patients with Colorectal Cancer: A Background for Future Studies

  • 0Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
International Journal of Molecular Sciences +

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May 25, 2024

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May 25, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

FOLFOX and XELOX cancer therapies alter body amino acid metabolism differently. Essential amino acids decreased with FOLFOX but increased or stayed stable with XELOX during treatment.

Area Of Science

  • Biochemistry
  • Oncology
  • Metabolomics

Background

  • Previous research indicates FOLFOX and XELOX chemotherapy regimens adversely affect skeletal muscle and extra-muscle metabolism.
  • Understanding the impact of these therapies on whole-body amino acid metabolism is crucial for patient care.

Purpose Of The Study

  • This pilot study aimed to evaluate changes in plasma amino acid levels (PAAL) and malondialdehyde (MDA) in colorectal cancer patients undergoing FOLFOX or XELOX therapy.
  • To assess if these therapies differentially affect whole-body amino acid metabolism and lipid peroxidation.

Main Methods

  • Fourteen colorectal cancer patients receiving FOLFOX (n=9) or XELOX (n=5) had plasma samples collected at baseline, during, and after three months of therapy.
  • Plasma amino acid levels (PAAL) and malondialdehyde (MDA) were measured.
  • Fifteen healthy subjects served as controls for baseline PAAL comparison.

Main Results

  • Significant alterations were observed in 87.5% of plasma essential amino acids (EAAs) and 38.4% of non-EAAs.
  • EAAs showed divergent changes: decreasing with FOLFOX and increasing or remaining stable with XELOX.
  • Baseline plasma MDA levels were elevated in both patient groups and showed a non-significant increase during therapy.

Conclusions

  • Three-month FOLFOX and XELOX therapies differentially impact plasma essential amino acid levels.
  • While both therapies affected amino acid profiles, baseline malondialdehyde levels were already high and did not significantly change during treatment.

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