Factors Influencing Long-Term Local Recurrence, Distant Metastasis, and Survival in Patients with Soft Tissue Sarcoma of the Extremities Treated with Radiotherapy
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View abstract on PubMed
Summary
This summary is machine-generated.Radiotherapy combined with surgery offers excellent outcomes for extremity soft-tissue sarcomas (ESTSs). Intensity-modulated radiation therapy (IMRT) improved local control, while liposarcoma indicated better survival.
Area Of Science
- Oncology
- Radiation Oncology
- Surgical Oncology
Background
- Prognostic factors for extremity soft-tissue sarcomas (ESTSs) treated with multimodal surgery and radiotherapy (RT) are debated.
- Diverse and heterogeneous studies contribute to this ongoing discussion.
Purpose Of The Study
- To retrospectively analyze prognostic factors in nonmetastatic ESTS patients treated with RT.
- To assess local control (LC), distant control (DC), overall survival (OS), and complications.
Main Methods
- Retrospective analysis of 169 nonmetastatic ESTS patients treated with RT (2007-2020).
- Assessment of LC, DC, OS, and complications.
- Univariate and multivariate analyses were performed to identify prognostic factors.
Main Results
- Excellent 5- and 10-year LC (91.7%, 84.2%), DC (76.8%, 74.1%), and OS (83.8%, 77.6%) were observed.
- Lower biologically effective dose (BED) (<75 BEDGy4) was associated with worse LC (p=0.015).
- Deep tumors, grade 2-3, and undifferentiated pleomorphic sarcoma (UPS) were linked to worse OS and DC. IMRT improved LC compared to 3DRT (p=0.018). Liposarcoma showed better OS.
Conclusions
- RT with surgical resection is well-tolerated and yields excellent long-term outcomes for ESTS.
- IMRT enhances local control compared to 3DRT.
- Liposarcoma is a favorable prognostic factor for OS; high-grade and deep tumors are associated with poorer outcomes.
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