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Glucose-to-lymphocyte Ratio (glr) As An Independent Prognostic Factor In Patients With Resected Pancreatic Ductal Adenocarcinoma-cohort Study.

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Glucose-to-lymphocyte Ratio (glr) As An Independent Prognostic Factor In Patients With Resected Pancreatic Ductal Adenocarcinoma-cohort Study.

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Glucose-to-Lymphocyte Ratio (GLR) as an Independent Prognostic Factor in Patients with Resected Pancreatic Ductal

Su-Hyeong Park¹, In-Cheon Kang², Seung-Soo Hong^3,4

¹Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon 22711, Republic of Korea.

|May 25, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

An elevated glucose-to-lymphocyte ratio (GLR) predicts poor survival in pancreatic cancer patients. This preoperative biomarker, along with tumor markers and symptoms, helps identify high-risk individuals for pancreatic ductal adenocarcinoma (PDAC) needing closer monitoring.

Keywords:

marker pancreatic cancer pancreatic ductal adenocarcinoma pancreatic neoplasm survival

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Area of Science:

Oncology
Biomarkers
Surgical Oncology

Background:

Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy with poor prognosis.
Identifying reliable prognostic biomarkers for early risk stratification is crucial for improving patient outcomes.

Purpose of the Study:

To evaluate the prognostic value of an elevated glucose-to-lymphocyte ratio (GLR) in patients with PDAC undergoing surgical resection.
To identify preoperative predictors of disease-specific survival in PDAC patients.

Main Methods:

Retrospective analysis of 338 PDAC patients who underwent surgical resection.
Determination of the optimal GLR cutoff value using the Contal and O'Quigley method.
Multivariate analysis to identify independent predictors of long-term survival.

Main Results:

Elevated GLR correlated with aggressive tumor features, including high CA 19-9 levels and larger tumor size.
Independent predictors of poor prognosis were GLR > 92.72, CA 19-9 > 145.35, and presence of symptoms.
Patients were stratified into three groups based on these factors, showing significantly different 5-year survival rates (50.2%, 34.6%, and 11.7%).

Conclusions:

An elevated preoperative GLR is a significant independent predictor of poor prognosis in PDAC patients.
The GLR, combined with other clinical factors, aids in risk stratification and prognosis.
Further prospective studies are warranted to validate these findings.