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Related Experiment Video

Updated: Jun 25, 2025

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Glucose-to-Lymphocyte Ratio (GLR) as an Independent Prognostic Factor in Patients with Resected Pancreatic Ductal

Su-Hyeong Park1, In-Cheon Kang2, Seung-Soo Hong3,4

  • 1Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon 22711, Republic of Korea.

Cancers
|May 25, 2024
PubMed
Summary
This summary is machine-generated.

An elevated glucose-to-lymphocyte ratio (GLR) predicts poor survival in pancreatic cancer patients. This preoperative biomarker, along with tumor markers and symptoms, helps identify high-risk individuals for pancreatic ductal adenocarcinoma (PDAC) needing closer monitoring.

Keywords:
markerpancreatic cancerpancreatic ductal adenocarcinomapancreatic neoplasmsurvival

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Area of Science:

  • Oncology
  • Biomarkers
  • Surgical Oncology

Background:

  • Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy with poor prognosis.
  • Identifying reliable prognostic biomarkers for early risk stratification is crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the prognostic value of an elevated glucose-to-lymphocyte ratio (GLR) in patients with PDAC undergoing surgical resection.
  • To identify preoperative predictors of disease-specific survival in PDAC patients.

Main Methods:

  • Retrospective analysis of 338 PDAC patients who underwent surgical resection.
  • Determination of the optimal GLR cutoff value using the Contal and O'Quigley method.
  • Multivariate analysis to identify independent predictors of long-term survival.

Main Results:

  • Elevated GLR correlated with aggressive tumor features, including high CA 19-9 levels and larger tumor size.
  • Independent predictors of poor prognosis were GLR > 92.72, CA 19-9 > 145.35, and presence of symptoms.
  • Patients were stratified into three groups based on these factors, showing significantly different 5-year survival rates (50.2%, 34.6%, and 11.7%).

Conclusions:

  • An elevated preoperative GLR is a significant independent predictor of poor prognosis in PDAC patients.
  • The GLR, combined with other clinical factors, aids in risk stratification and prognosis.
  • Further prospective studies are warranted to validate these findings.