Novel Techniques, Biomarkers and Molecular Targets to Address Cardiometabolic Diseases

Area of Science:

• Cardiology
• Metabolic Diseases
• Genetics

Background:

• Cardiometabolic diseases (CMDs) encompass conditions like hypertension, diabetes, heart failure, coronary artery disease, and stroke.
• The rising prevalence of CMDs contributes significantly to cardiovascular morbidity and mortality.
• There is an urgent need for advanced diagnostic and therapeutic approaches to manage CMDs effectively.

Purpose of the Study:

• To explore novel diagnostic and therapeutic strategies for cardiometabolic diseases.
• To investigate the potential of innovative clinical methods and epigenetic alterations in CMD management.
• To address the challenges in translating research findings into clinical practice for CMDs.

Main Methods:

• Evaluation of epicardial adipose tissue.
• Assessment of ventricular-arterial coupling.
• Utilization of exercise tolerance studies.
• Analysis of epigenetic changes, including noncoding RNAs, chromatin modulation, and cellular senescence.

Main Results:

• Innovative clinical methods can elucidate multifaceted mechanisms of CMDs.
• Epigenetic changes show potential as novel biomarkers and therapeutic targets for CMDs.
• Current research highlights promising data but faces challenges in clinical translation.

Conclusions:

• Further investigation into the complex pathophysiology of CMDs is essential.
• Integrating novel clinical and epigenetic approaches may improve CMD management.
• Bridging the gap between basic research and clinical practice is crucial for advancing CMD care.