Related Experiment Video
Updated: Jun 25, 2025
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
What do We Know about Cryptic Aspergillosis?
Nicholas Geremia1,2, Federico Giovagnorio3, Agnese Colpani4
1Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale Dell'Angelo, 30174 Venice, Italy.
Abstract:
Cryptic Aspergillus species are increasingly recognized as pathogens involved in human disease. They are ubiquitarian fungi with high tenacity in their environment and can express various resistance mechanisms, often due to exposure to antifungal agents employed in agriculture and farming. The identification of such species is increasing thanks to molecular techniques, and a better description of this type of pathogen is granted. Nevertheless, the number of species and their importance in the clinical setting still need to be well studied. Furthermore, their cross-sectional involvement in animal disease, plants, and human activities requires a multidisciplinary approach involving experts from various fields. This comprehensive review aims to provide a sharp vision of the cryptic Aspergillus species, from the importance of correct identification to the better management of the infections caused by these pathogens. The review also accentuates the importance of the One Health approach for this kind of microorganism, given the interconnection between environmental exposure and aspergillosis, embracing transversely the multidisciplinary process for managing the cryptic Aspergillus species. The paper advocates the need for improving knowledge in this little-known species, given the burden of economic and health implications related to the diffusion of these bugs.
Insights
Cryptic Aspergillus species are emerging fungal pathogens. Understanding their identification and management is crucial for human and animal health, emphasizing a One Health approach.
Area of Science:
- Mycology
- Infectious Diseases
- Public Health
Background:
- Cryptic Aspergillus species are increasingly identified as significant human pathogens.
- These ubiquitous fungi exhibit environmental tenacity and possess resistance mechanisms, often linked to agricultural antifungal use.
- Current knowledge on the number of cryptic species and their clinical impact remains limited.
Purpose of the Study:
- To provide a comprehensive overview of cryptic Aspergillus species, focusing on accurate identification.
- To discuss the improved management strategies for infections caused by these pathogens.
- To highlight the necessity of a One Health approach for understanding and controlling these microorganisms.
Main Methods:
- Comprehensive literature review.
- Analysis of current molecular identification techniques.
- Synthesis of information on antifungal resistance and clinical significance.
Main Results:
- Molecular techniques are improving the identification of cryptic Aspergillus species.
- These fungi pose a cross-sectional threat across animal, plant, and human health sectors.
- A multidisciplinary approach is essential for effective management.
Conclusions:
- Accurate identification and a One Health strategy are vital for managing cryptic Aspergillus infections.
- Further research is needed to fully understand the scope and implications of these pathogens.
- Addressing the economic and health burdens associated with these fungi requires enhanced knowledge and collaboration.
More Related Videos
15:01Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung
Published on: September 18, 2021
08:01Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
Related Concept Videos
01:23Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
01:28Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...