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Serum Malondialdehyde-Modified Low-Density Lipoprotein as a Risk Marker for Peripheral Arterial Stiffness in
Wei-Nung Liu1,2,3, Yi-Chiung Hsu2, Chia-Wen Lu1,4
1Department of Medicine, Hualien Armed Forces General Hospital, Hualien 97144, Taiwan.
Medicina (Kaunas, Lithuania)
|May 25, 2024
Summary
Higher levels of malondialdehyde-modified low-density lipoprotein (MDA-LDL), an oxidative stress marker, are linked to peripheral arterial stiffness (PAS) in hemodialysis patients. A serum MDA-LDL level of 80.91 mg/dL is identified as a key predictor of PAS.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Biochemistry
Background:
- Peripheral arterial stiffness (PAS), measured by brachial-ankle pulse wave velocity (baPWV), is a significant cardiovascular disease (CVD) biomarker in hemodialysis (HD) patients.
- Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is an oxidative stress marker associated with atherosclerosis and CVD.
Purpose of the Study:
- To investigate the association between serum MDA-LDL and PAS in HD patients.
- To determine the optimal cutoff value of serum MDA-LDL for predicting PAS.
Main Methods:
- Cross-sectional study of 100 HD patients.
- Serum MDA-LDL quantified by ELISA; baPWV measured by volume plethysmography.
- Multivariable logistic regression and ROC curve analysis used to assess associations and identify cutoff values.
Main Results:
- Higher serum MDA-LDL, older age, and elevated C-reactive protein were independently associated with PAS (ORs: 1.014, 1.044, 3.697, respectively).
- The optimal MDA-LDL cutoff for predicting PAS was 80.91 mg/dL, with 79.25% sensitivity and 59.57% specificity.
Conclusions:
- Elevated serum MDA-LDL levels (≥80.91 mg/dL) are independently associated with PAS in HD patients.
- Oxidative stress, indicated by MDA-LDL, is implicated in PAS development.
- Targeting MDA-LDL may offer a therapeutic strategy to mitigate cardiovascular risk in HD patients.
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