Related Experiment Video
Updated: Jun 25, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Phenotype and Clinicoradiological Differences in Multifocal and Focal Bronchiectasis
Jelena Jankovic1,2, Aleksandar Jandric1, Natasa Djurdjevic1,2
1Clinic for Pulmonology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Multifocal bronchiectasis, unlike focal, is linked to more females, hemoptysis, and hospitalizations. This suggests multifocal bronchiectasis may indicate greater disease severity and poorer outcomes.
Area of Science:
- Pulmonology
- Radiology
- Clinical Medicine
Background:
- Bronchiectasis is a chronic respiratory condition with diverse causes and presentations.
- Limited research compares focal and multifocal bronchiectasis characteristics and prognosis.
Purpose of the Study:
- To compare clinical characteristics, severity, and prognostic implications of focal versus multifocal bronchiectasis.
- To identify differences in presentation and outcomes between the two bronchiectasis types.
Main Methods:
- 126 patients with CT-verified bronchiectasis were analyzed.
- Data included demographics, symptoms (hemoptysis), comorbidities, BMI, and smoking history.
- Radiological severity (modified Reiff score) and bronchiectasis type (focal/multifocal) were assessed.
Main Results:
- No significant differences in age, smoking, comorbidity, or BMI between focal and multifocal groups.
- Multifocal bronchiectasis showed higher rates of females, hemoptysis, and hospitalizations.
- Multifocality was associated with moderate severity, post-infective/asthma phenotypes, and immunodeficiency.
Conclusions:
- Multifocal bronchiectasis is not linked to age, exacerbations, or radiological phenotype.
- It appears associated with post-infective causes, immunodeficiency, frequent hospitalizations, and increased severity.
- Multifocal bronchiectasis may serve as a biomarker for worse prognosis in patients.
More Related Videos
02:09Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
04:10Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy
Published on: July 19, 2024
Related Concept Videos
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Chronic Obstructive Pulmonary Disease-I: Introduction