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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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Residual Cardiovascular Risk: Role of Remnants Cholesterol, Monocyte/HDL Ratio and Lipoprotein Ratios on Personalized
Vincenzo Sucato1, Francesco Comparato1, Antonella Ortello1
1Division of Cardiology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University Hospital Paolo Giaccone, University of Palermo, 90127 Palermo, Italy.
Journal of Personalized Medicine
|May 25, 2024
Summary
Residual risk (RR) in cardiovascular disease refers to the chance of events despite controlled risk factors. Addressing undertreated factors like triglycerides is key to reducing overall cardiovascular risk.
Area of Science:
- Cardiology
- Preventive Medicine
- Public Health
Background:
- Cardiovascular diseases (CVDs) are the leading global cause of mortality.
- Current prevention strategies have limitations, even with effective medications.
- Residual risk (RR) significantly contributes to the overall cardiovascular risk profile.
Purpose of the Study:
- To highlight the concept of residual risk in cardiovascular disease.
- To emphasize the impact of undertreated risk factors on residual risk.
- To advocate for integrated strategies to manage residual risk.
Main Methods:
- Review of existing literature on cardiovascular risk factors and management.
- Analysis of the contribution of specific undertreated factors (e.g., triglycerides) to residual risk.
- Synthesis of evidence-based prevention strategies.
Main Results:
- Residual risk accounts for a substantial percentage of overall cardiovascular risk.
- Inadequate management of factors like hypertension, hypercholesterolemia, and triglyceride levels contributes significantly to RR.
- An integrated approach combining lifestyle, pharmacological, and nutraceutical interventions is necessary.
Conclusions:
- Effective reduction of global cardiovascular risk requires comprehensive management of residual risk.
- Integrated interventions targeting lifestyle, pharmacological, and nutraceutical approaches are essential.
- Addressing undertreated risk factors is crucial for improving cardiovascular outcomes.
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