F10 Gene Expression and Ethnic Disparities Present in Papillary Thyroid Carcinoma

Area of Science:

• Oncology
• Genetics
• Molecular Biology

Background:

• Papillary thyroid carcinoma (PTC) disproportionately affects Hispanic women, often presenting as advanced disease.
• Coagulation factor X (F10) is implicated in inhibiting cancer cell migration, but its role in ethnic disparities in PTC is understudied.

Purpose of the Study:

• To investigate differential F10 gene expression in Hispanic versus non-Hispanic female patients with PTC.
• To evaluate the association between F10 expression levels and tumor recurrence risk in PTC.

Main Methods:

• RNA-sequencing data from The Cancer Genome Atlas (TCGA) database were analyzed.
• Expression levels of the F10 gene were compared between Hispanic (n=25) and non-Hispanic (n=166) white female PTC patients.

Main Results:

• A significant 2.06-fold increase in F10 expression was found in disease-free tumors compared to recurrent PTC tumors (p < 0.05).
• Non-Hispanic patients exhibited a 1.74-fold higher F10 gene expression compared to Hispanic patients.
• Low F10 expression was associated with a 1.82-fold higher probability of tumor recurrence.

Conclusions:

• F10 expression levels correlate with PTC recurrence risk and ethnic disparities.
• F10 is a potential prognostic biomarker for PTC, offering insights into ethnic variations in cancer susceptibility.
• Findings support the need for targeted interventions to address ethnic disparities in PTC diagnosis and treatment.