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Updated: Jun 25, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Review: A Contemporary, Multifaced Insight into Psoriasis Pathogenesis
Rucsandra Cristina Dascălu1, Andreea Lili Bărbulescu2, Loredana Elena Stoica3
1Department of Rheumatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Journal of Personalized Medicine
|May 25, 2024
Summary
Psoriasis pathogenesis involves genetic factors, immune cells, and the IL-23/IL-17 axis, leading to chronic inflammation. Understanding these complex pathways, including microbiome influences, is key to developing targeted immunotherapies.
Area of Science:
- Immunology
- Genetics
- Dermatology
Background:
- Psoriasis is a chronic inflammatory autoimmune disease with a strong genetic basis.
- Immune cell interactions and cytokine signaling, particularly the IL-23/IL-17 axis, drive disease pathology.
- Genetic factors, including MHC region loci and PSORS1, significantly contribute to psoriasis development.
Purpose of the Study:
- To provide insight into the multifaceted pathogenesis of psoriasis.
- To explore the interplay of genetic, immunological, and environmental factors in disease development.
- To highlight advancements in understanding psoriasis for improved therapeutic strategies.
Main Methods:
- Review of genome-wide association studies (GWASs) for genetic insights.
- Analysis of immunological pathways, focusing on the IL-23/IL-17 axis.
- Examination of the role of microbiome dysbiosis in psoriasis etiology.
Main Results:
- Psoriasis pathogenesis is complex, involving immune cells, genetic alterations, and external factors.
- The IL-23/IL-17 axis perpetuates inflammation and keratinocyte activation, causing psoriatic lesions.
- Both cutaneous and gut microbiome dysbiosis contribute to the inflammatory process.
Conclusions:
- A comprehensive understanding of psoriasis pathogenesis is crucial for developing targeted immunotherapies.
- Interplay between genetic predisposition, immune responses, and microbiota influences disease progression.
- Novel therapeutic targets are emerging from research into genetic, epigenetic, and immunological factors.
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