Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Separation and determination of furanocoumarins in shatian pomelo juice by HPLC-MS].

Se pu = Chinese journal of chromatography·2007
Same author

Effect of neuregulin-1 on histopathological and functional outcome after controlled cortical impact in mice.

Journal of neurotrauma·2007
Same author

Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma.

Cancer letters·2007
Same author

Compound Salvia droplet pill, a traditional Chinese medicine, for the treatment of unstable angina pectoris: a systematic review.

Medical science monitor : international medical journal of experimental and clinical research·2007
Same author

Ezrin silencing by small hairpin RNA reverses metastatic behaviors of human breast cancer cells.

Cancer letters·2007
Same author

The effect of nitric oxide on metal release from metallothionein-3: gradual unfolding of the protein.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry·2007
Same journal

Correction: Kang et al. Fluid Flow to Electricity: Capturing Flow-Induced Vibrations with Micro-Electromechanical-System-Based Piezoelectric Energy Harvester. <i>Micromachines</i> 2024, <i>15</i>, 581.

Micromachines·2026
Same journal

Femtosecond Laser Texturing of Wood Coatings with Bio-Based Epoxy and Wax Additives for Enhanced Hydrophobicity.

Micromachines·2026
Same journal

Engineering of Optoelectronic Devices for Renewable Energy Applications.

Micromachines·2026
Same journal

Phase Transformation and Electrochemical Behavior of Hexagonal TiO<sub>2</sub> Nanotubes Under Different Annealing Temperatures and Heating Rates.

Micromachines·2026
Same journal

Process Optimization and Predictive Modeling of Femtosecond Laser Precision Milling for Commercial PMMA Slices.

Micromachines·2026
Same journal

A Hybrid Preprocessing Multi-Objective Surrogate Model for Thermal MEMS Actuators.

Micromachines·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2025

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
06:12

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

1.4K

Recent Advances in Microfluidic-Based Extracellular Vesicle Analysis.

Jiming Chen1,2,3, Meiyu Zheng1,2,3, Qiaoling Xiao1,2,3

  • 1Department of Basic Medicine, Xiamen Medical College, Xiamen 361023, China.

Micromachines
|May 25, 2024
PubMed
Summary
This summary is machine-generated.

Microfluidics technology offers a promising solution for isolating and detecting extracellular vesicles (EVs), overcoming limitations of traditional methods for improved disease diagnosis and treatment. This approach enhances EV capture efficiency and enables precise, high-throughput analysis.

Keywords:
EV detectionEV isolationextracellular vesiclesmicrofluidics

More Related Videos

Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration
06:28

Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration

Published on: February 2, 2024

706
Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

300

Related Experiment Videos

Last Updated: Jun 25, 2025

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
06:12

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

1.4K
Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration
06:28

Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration

Published on: February 2, 2024

706
Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

300

Area of Science:

  • Biotechnology and Biomedical Engineering
  • Cell Biology and Molecular Medicine

Background:

  • Extracellular vesicles (EVs) are crucial intercellular messengers with significant diagnostic and therapeutic potential.
  • Conventional EV isolation and detection methods suffer from low purity, poor recovery, and limited sensitivity, hindering clinical applications.
  • There is an urgent need for standardized, efficient methods for EV isolation and detection.

Purpose of the Study:

  • To review traditional and microfluidic-based techniques for extracellular vesicle (EV) isolation and detection.
  • To highlight the advantages of microfluidics in improving EV capture efficiency, targeting, and analytical sensitivity.
  • To explore the potential of microfluidics for automated, high-throughput EV analysis in clinical settings.

Main Methods:

  • Review of existing literature on traditional EV isolation and detection techniques.
  • Analysis of microfluidic-based methodologies for EV isolation and detection, focusing on their principles and performance.
  • Comparison of microfluidic approaches with conventional methods regarding efficiency, purity, recovery, sensitivity, and specificity.

Main Results:

  • Microfluidic technology offers superior integration, reduced analysis time, and lower sample/reagent consumption compared to traditional methods.
  • Microfluidic devices demonstrate enhanced capture efficiency and precise targeting capabilities for extracellular vesicles (EVs).
  • Microfluidics enables sensitive and specific analytical detection of EVs, paving the way for clinical utility.

Conclusions:

  • Microfluidics presents a transformative solution to the bottlenecks in EV isolation and detection.
  • The technology holds significant potential for achieving automated and high-throughput analysis of EVs from clinical samples.
  • Advancements in microfluidic platforms are critical for realizing the full clinical potential of extracellular vesicles (EVs).