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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Related Experiment Video

Updated: Jun 25, 2025

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
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Integrin-Targeting Strategies for Adenovirus Gene Therapy.

Glen R Nemerow1

  • 1Department of Immunology, The Scripps Research Institute, 10666 North Torrey Pines Rd, La Jolla, CA 92037, USA.

Viruses
|May 25, 2024
PubMed
Summary
This summary is machine-generated.

Human adenoviruses (AdV) use arginine-glycine-aspartic acid (RGD) sequences to bind vitronectin (αv) integrins, facilitating viral entry and capsid disassembly. This interaction is key for AdV infection and potential cancer therapies.

Keywords:
adenovirusbioimagingextracellular matrix proteinsfiberintegrinsnanoparticlespenton base

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Area of Science:

  • Virology
  • Cell Biology
  • Biotechnology

Background:

  • Many human adenoviruses (AdV) possess arginine-glycine-aspartic acid (RGD) motifs.
  • These RGD sequences mediate binding to vitronectin-binding (αv) integrins on host cells.
  • Integrin binding is essential for AdV entry and subsequent infection processes.

Purpose of the Study:

  • To review the fundamental aspects of AdV-host interactions mediated by integrins.
  • To discuss the role of integrins in AdV entry, endocytosis, and capsid disassembly.
  • To explore recent advancements in engineering AdV vectors and nanoparticles for targeting αv integrins in cancer therapy and bioimaging.

Main Methods:

  • Literature review focusing on AdV-host interactions via integrins.
  • Analysis of AdV entry mechanisms involving RGD sequences and αv integrins.
  • Discussion of bioengineering strategies for AdV vectors and nanoparticles.

Main Results:

  • AdV RGD sequences are critical for recognizing and binding to αv integrins.
  • Integrin-mediated interactions initiate receptor-endocytosis and promote AdV capsid disassembly.
  • Engineered AdV vectors and nanoparticles targeting αv integrins show promise for cancer treatment and imaging.

Conclusions:

  • Integrin-AdV interactions are fundamental to viral infection.
  • Targeting αv integrins offers a promising strategy for developing novel cancer therapeutics and diagnostic tools.