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Updated: Jun 25, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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Persistence in the Methadone Maintenance Program and Its Relationship with the Medication Regimen Complexity Index in

Elena Alba Álvaro-Alonso1, María Del Carmen Gómez-Álvarez2, Beatriz Segovia-Tapiador3

  • 1Pharmacy Department, Infanta Leonor University Hospital, Av. Gran Vía del Este, 80, 28031 Madrid, Spain.

Pharmaceuticals (Basel, Switzerland)
|May 25, 2024
PubMed

Insights

The Medication Regimen Complexity Index (MRCI) may not accurately predict methadone maintenance program persistence in opioid-dependent patients. New predictors like age and comorbidities are identified for better treatment outcomes.

Area of Science:

  • Pharmacology
  • Psychiatry
  • Public Health

Background:

  • The Medication Regimen Complexity Index (MRCI) is established for assessing pharmacotherapeutic regimen complexity (CPR) and is linked to reduced adherence.
  • However, the MRCI's utility in opioid-dependent patients (ODP) and their methadone maintenance program (MMP) persistence remains uninvestigated.

Purpose of the Study:

  • To determine MMP persistence and MRCI scores in a cohort of ODP.
  • To analyze the relationship between MRCI, MMP persistence, and other relevant variables.

Main Methods:

  • An observational study was conducted on adults diagnosed with opiate-dependency (DSM-5) within an MMP center.
  • MMP persistence was defined using a novel, researcher-created scale with five weighted items.

Main Results:

  • A new definition for MMP persistence was established.
  • Age, comorbidities, and methadone maintenance doses were identified as significant predictors of MMP persistence.
  • The MRCI did not appear to be a reliable tool for predicting MMP persistence in this cohort.

Conclusions:

  • The MRCI may not be suitable for assessing MMP persistence in ODP due to multifactorial influences beyond CPR.
  • Further research is needed to develop precise tools for selecting and stratifying ODP to enhance treatment persistence.
Keywords:
adherencemedication regimen complexity indexmethadone maintenance programopioid-dependent patientspersistence

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