Testosterone Therapy for Late-Onset Hypogonadism: A Clinical, Biological, and Analytical Approach Using Compounded...

Area of Science:

• Endocrinology
• Dermatology
• Pharmaceutical Sciences

Background:

• Testosterone is crucial for male health, declining with age.
• Hypogonadism presents symptoms that impact quality of life.
• Topical testosterone offers a therapeutic route for hormone replacement.

Purpose of the Study:

• To assess the clinical efficacy and stability of compounded topical testosterone gel.
• To evaluate testosterone's skin permeation characteristics.
• To determine the suitability of topical testosterone for long-term hypogonadism management.

Main Methods:

• Retrospective analysis of a patient receiving 5% compounded testosterone gel.
• Evaluation of serum total testosterone levels and androgen deficiency questionnaire results.
• In vitro skin permeation studies using the Franz finite dose model and human cadaver skin.
• Analytical testing for stability-indicating assay methods for 0.5% and 20% testosterone gels.

Main Results:

• The patient experienced improved hypogonadal symptoms and achieved optimal serum testosterone levels.
• In vitro studies confirmed testosterone penetration through human cadaver skin.
• Compounded testosterone gels (0.5% and 20%) exhibited extended stability.

Conclusions:

• Topical testosterone gel is clinically effective for alleviating hypogonadal symptoms.
• Compounded topical testosterone formulations are stable and demonstrate adequate skin permeation.
• Personalized topical testosterone therapy is a viable therapeutic option for hypogonadal patients.